When you get to Sixaola (Frontier with Panama) must complete the immigration procedures in Costa Rica and Panama.
Arriving at Guabito (Panamanian side of the frontier) you can go to Almirante, by bus, minibus or taxi according to your choice, which will charge you approximately a fare of $10.
In Almirante you must take the boat that will take you to Bocas del Toro. The trip to Bocas del Toro (Colon Island) lasts approximately 35 minutes.